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PLA2R-AB is elevated months to years before NNRP as a surrogate marker for earliest clinical evidence of MN. Examples of MN cases showing seropositive PLA2R-AB before abnormal prediagnostic NNRP. The PLA2R-AB levels are plotted on the y axis and the horizontal dotted line is the cut-off value for determining seropositivity. The first clinical evidence of abnormal prediagnostic NNRP is indicated by time zero.
