Table 3.

Effect of two doses of NaHCO₃ on urinary and serum measurements

Measurement	Baseline	Wk 12	Wk 28
24-h urinary ammonium (meq/d)
Placebo	16.3, 7.5–37.9	19.8, 10.5–40.8	16.7, 10.3–38.8
LD-NaHCO3	18.3, 7.9–30.9	10.7, 5.2–28.6a	12.8, 5.5–25.7a
HD-NaHCO3	18.9, 10.1–38.2	10.3, 3.7–30.5b	10.9, 3.4–25.9b,c
Urinary pH
Placebo	5.7, 5.1–6.6	5.6, 5.2–6.6	5.8, 5.3–7.0
LD-NaHCO3	5.8, 5.3–6.5	6.8, 5.9–7.3a	6.7, 5.6–7.1a
HD-NaHCO3	5.7, 5.2–6.4	6.9, 6.0–7.3b	6.9, 5.5–7.4b
Serum bicarbonate (meq/L)
Placebo	24, 22–27	23, 20–27	24, 20–28
LD-NaHCO3	25, 22–27	25, 22–28a	25, 20–28
HD-NaHCO3	25, 21–28	26, 22–30b,c	26, 22–29b,c
24-h urinary sodium (meq/d)
Placebo	161, 85–247	167, 73–286	162, 85–263
LD-NaHCO3	150, 69–220	176, 103–303	177, 90–241
HD-NaHCO3	156, 80–268	190, 105–298b	197, 119–327b,c
24-h urinary chloride (meq/d)
Placebo	161, 80–231	166, 75–297	151, 81–249
LD-NaHCO3	148, 75–222	147, 74–257	151, 73–203
HD-NaHCO3	154, 70–266	144, 82–248	162, 87–257c
24-h urinary potassium (meq/d)
Placebo	53, 37–84	57, 27–100	63, 21–93
LD-NaHCO3	52, 30–92	58, 31–90	60, 30–84
HD-NaHCO3	60, 32–101	63, 38–100	61, 36–98
Random urinary ACR (mg/g)
Placebo	147, 4.4–1494	173, 5.0–1251	176, 4.2–1488
LD-NaHCO3	222, 11.5–1421	213, 13.6–2017	220, 14.1–1899
HD-NaHCO3	176, 9.2–1433	205, 7.7–1671b	195, 7.8–2265b

The values shown are the median, 10th–90th percentiles of each variable.

^aP<0.05 for linear mixed model estimate of the change from baseline for LD versus placebo at the visit.

^bP<0.05 for linear mixed model estimate of the change from baseline for HD versus placebo at the visit.

^cP<0.05 for linear mixed model estimate of the change from baseline for HD versus LD at the visit.