Figure 5.

(A) Pig kidney graft survival in baboons receiving either conventional (tacrolimus-based; group A) or anti-CD40 mAb–based (group B) immunosuppressive therapy. Median pig kidney graft survival in group B (186 days) was significantly longer than in group A (13 days) (P<0.01). Reproduced from reference 38, with permission). (B) Histopathology of thrombotic glomerulopathy in a pig kidney of group A. Glomerular histopathology included thrombotic microangiopathic glomerulopathy, glomerular thrombi, mesangial thickening, and glomerular edema (expansion of Bowman’s space). Hematoxylin and eosin stain, original magnification ×400. Reproduced from reference 38, with permission.