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. 2019 Dec 23;14:10047–10060. doi: 10.2147/IJN.S231167

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© 2019 Shamul et al.

This work is published by Dove Medical Press Limited, and licensed under a Creative Commons Attribution License. The full terms of the License are available at http://creativecommons.org/licenses/by/4.0/. The license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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fVPM exhibit enhanced pharmacokinetic properties compared to sVPM in an ectopic human GBM tumor mouse flank model. (A) sVPM and fVPM in blood at 5, 10, 30, 60, 120, 210, and 420 min timepoints, (B) 8 hrs and 24 hrs biodistribution for tumors and major organs (n=2, mean ± SD, one-way ANOVA with Bonferroni’s multiple comparisons test (**p ≤ 0.01)). (C) Nanoparticle signal in tumors after 8 and 24 hrs (n=2, mean ± SD, one-way ANOVA with Bonferroni’s multiple comparisons test (***p ≤ 0.001, ****p ≤ 0.0001)). (D) sVPM and fVPM- treated animals under IVIS after 0 min, 30 mins, 60 mins, and 120 mins. Animals in the same image are replicates. Red circles in leftmost panels indicate the location of tumors.