2.
已发表NSCLC患者EGFR突变状态与PD-L1表达相关性的研究汇总
Published report that have studied the relationship of EGFR mutation and PD-L1 expression in NSCLC
| Author (Year) |
Ethnicity (Country) |
PD-L1 Ab | Patient number (EGFR mutation) |
Ad/Sq/other | Ⅰ/Ⅱ/Ⅲ/Ⅳ | Method | Cut-off | Influence |
| PD-L1: programmed death ligand 1; EGFR: epidermal growth factor receptor; NSCLC: non-small cell lung carcinoma; Ad: adenocarcinoma; Sq: squamous cell carcinoma. | ||||||||
| Azuma[9] (2014) | Asian (Japan) | Lifespan Bioscience | 164 (57) | 114/50 | 67/46/51/0 | IHC | Intensity×extent | Up |
| D’Incecco[18] (2015) | Caucasian (Italian) | Ab58810 | 125 (56) | 83/23/19 | 0/0/0/125 | IHC | ≥5% | Up |
| Tang[19] (2015) | Asian (China) | E1L3N | 170 (99) | Ad 145 Non-Ad 25 | 0/0/9/161 | IHC | H-score≥5% | Up |
| Song[20] (2016) | Asian (China) | Proteintech | 385 (205) | 385/0/0 | 121/79/185/0 | IHC | ≥5% | Up |
| Huynh[21] (2016) | Caucasian (America) | E1L3N | 261 (54) | 261/0/0 | 201/34/22/4 | IHC | ≥1%；≥5%；≥50% | Down |
| Ji[22] (2016) | Asian (China) | Ab174838 | 100 (60) | 100/0/0 | 42/27/41 | IHC | > 5% 2+ (moderate) | Down |
| Inoue[23] (2016) | Asian (Japan) | E1L3N | 654 (132） | 430/179/45 | 416/113/125 | IHC | H-score≥5 | Down |
| Dong[24] (2017) | Asian (China) | SP142 | 255 (Unclear) | Unclear | Unclear | IHC | < 5%；5%-49%；≥50% | Down |
| Takada[25] (2017) | Asian (Japan) | SP142 | 499 (112) | 417/82/0 | 354/82/63 | IHC | 1%; 5%; 10%; 50% | Down |
| Takada[26] (2018) | Asian (Japan) | SP142 | 441 (223) | 441/0/0 | 339/54/40/8 | IHC | 0%; 1%-4%; 5%-49%; ≥50% | Down |
| Lee[28] (2019) | Asian (Korea) | 22C3 | 1, 000 (424） | 785/188/27 | 621/167/140/30 | IHC | < 1%; 1%-49%; ≥50% | Down |
| Yang[29] (2014) | Asian (Taiwan) | Proteintech | 163 (97) | 163/0/0 | 163/0/0/0 | IHC | ≥5% | No |
| Yang[30] (2016) | Asian (Taiwan) | Proteintech | 105 (17) | 0/105/0 | 105/0/0/0 | IHC | ≥5% | No |
| Zhang[31] (2014) | Asian (China) | SAB 2900365 | 143 (76) | 143/0/0 | Ⅰ: 66; Ⅱ-Ⅲ: 77 | IHC | Quickscore (range 0-18) | No |
| Cooper[32] (2015) | Caucasian (Australian) | 22C3 | 678 (33) | 276/271/131 | 49/271/315 | IHC | ≥50% (any intensity) | No |
| Kim[33] (2015) | Asian (Korean) | E1L3N | 331 (7) | 0/331/0 | 131/118/79 | IHC | ≥10% (any intensity) | No |
| Schmidt[34] (2015) | Caucasian (German) | E1L3N | 321 (6) | 125/149/47 | 187/83/51 | IHC | ≥5% 2+ (moderate) | No |
| Gainor[35] (2016) | Caucasian (America) | E1L3N | 95 (68) | 48/9/1 | Unclear | IHC | ≥1%; ≥5%; ≥50% (any intensity) | No |
| Ameratunga[36](2016) | Caucasian (Australian) | E1L3N | 522 (27) | 288/182/57 | Unclear | IHC | > 5% 2+ (moderate) | No |