Table 1.

Differentially expressed genes (DEGs) among PBS injected TF, TR, and D groups relative to W. DEGs with a fold change ≥3 are shown in bold (significant by Baggerley’s test, normalized FDR correction P-value < 0.01)

Tissue	Gene	Annotation	Fold change
			TR/W	TF/W	D/W
Head kidney	unigene22417332	Aquaporin 1	−1.5	1.1	−3.5
	unigene22417191	ATP-dependent RNA helicase DHX30-like	6.4	3.1	1.7
	unigene22417189	ATP-dependent RNA helicase DHX30-like	4.9	2.6	1.6
	unigene22386458	B chain crystal structure of avidin	2.8	4.1	−2.0
	unigene22392248	Complement C1q-like protein 4 precursor	−3.6	−1.9	−2.0
	unigene22390619	Leucine-rich repeat-containing protein 19	4.6	3.0	1.7
	unigene22396071	Methyltransferase DDB-like	6.2	4.1	3.1
	unigene22408729	Perforin-1-like isoform X1	−1.5	−1.1	−3.7
	unigene22418289	Sodium channel protein type 4 subunit alpha B	53.9	11.9	−2.4
	unigene22385893	Uncharacterized protein LOC109903204	−2.2	−1.4	−5.2
	unigene22389921	Uncharacterized protein LOC109904151	−1.5	−1.0	−3.6
	unigene22393685	Uromodulin	−1.3	1.1	−3.6
	unigene22425942	ORF2 protein	3.8	1.2	1.2
Liver	unigene22426268	Fatty acid-binding protein 1	−1.1	−4.0	−2.7
	unigene22387365	Microfibril-associated glycoprotein 4-like	−3.2	−1.5	1.3
	unigene22426266	Saxitoxin and tetrodotoxin-binding protein 1	−3.5	−1.5	1.3
	unigene22418289	Sodium channel protein type 4 subunit alpha B	30.2	8.9	−1.0
	unigene22391480	Transmembrane protein 116	−8.9	−2.3	1.0
	unigene22426238	C-C motif chemokine 19-like	−4.3	3.0	1.8

PBS phosphate-buffered saline, PGN peptidoglycan, Poly I:C polyinosinic-polycytidylic acid. W, non-transgenic (wild-type) coho salmon on a full satiation ration, TF GH transgenic coho salmon on a full satiation ration, TR GH transgenic coho salmon on restricted ration equal to that consumed by W, D domesticated coho salmon on a full satiation ration