Fig. 4.

Leukemic cells adopt hypoxia like glycolytic signaling under normoxic conditions and various glycolytic genes are upregulated across multiple AML subtypes. a A number of glycolysis and TCA genes are upregulated in leukemia cell lines compared to normal CB CD34⁺ cells under normoxic conditions. A heatmap of gene array data is shown whereby expression levels in CB CD34⁺ cells were set to 1. b Expression of SLC2A1 and SLC2A3 under normoxic and hypoxic conditions in normal CB CD34⁺ cells and leukemia lines. c Expression of glycolysis, TCA, and glutaminolysis genes in primary AML patient samples. Data were taken from the bloodspot database. d Expression of HIF1, HIF2, and ARNT in primary AML patient samples