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. 2019 Dec 27;21:152. doi: 10.1186/s13058-019-1238-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Differential expression analysis identified metastasis-associated genes. a, b Tumor-derived cell lines with different a spindle- or b cobblestone-like epithelial morphology. c Schematic of the experimental metastasis assay. Lung with metastatic tumor nodules shown. d Histology of the lung with tumor nodules. e Volcano plot depicting the differentially expressed genes when comparing metastatic sarcomatoid carcinomas vs adenocarcinomas (see the “Methods” section)