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. 2019 Dec 27;19:357. doi: 10.1186/s12935-019-1082-9

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© The Author(s) 2019

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — CDC42 was required for miR-149-mediated progression of NB. a The expression of CDC42 protein was measured in SK-N-BE(2)C and SK-N-SH cells transfected with miR-NC, miR-149, miR-149 + pcDNA or miR-149 + CDC42 by western blot. The IC50 of Dox (b) and cell proliferation (c) was analyzed in SK-N-BE(2)C and SK-N-SH cells transfected with miR-NC, miR-149, miR-149 + pcDNA or miR-149 + CDC42 by MTT. d Colony formation was measured in SK-N-BE(2)C and SK-N-SH cells transfected with miR-NC, miR-149, miR-149 + pcDNA or miR-149 + CDC42. e Cell apoptosis was detected in SK-N-BE(2)C and SK-N-SH cells transfected with miR-NC, miR-149, miR-149 + pcDNA or miR-149 + CDC42 by flow cytometry. *P < 0.05, **P < 0.01, compared with miR-NC or miR-149 + pcDNA group