Table 1.
Characteristics of the derivation and validation cohorts
| Derivation cohort n = 955 | Validation cohort n = 1201 | |
|---|---|---|
| Age, y, median ± SD | 53.5 ± 8.3 | 50.7 ± 11.4 |
| Sex, male, n (%) | 518 (54.2) | 743 (61.9) |
| BMI, kg/m2, median ± SD | 24.3 ± 3.6 | 24.6 ± 4.3 |
| Current or ex-smoking, n (%) | 303 (31.7) | 370 (30.8) |
| Alcohol consumption, n (%) | 452 (47.3) | 391 (32.6) |
| Diabetes, n (%) | 38 (4.0) | 128 (10.7) |
| Family history, n (%) | 87 (9.1) | 71 (5.9) |
| Diet, n (%) | NA | |
| Vegetable | 333 (34.9) | |
| Meat | 187 (19.6) | |
| Unspecific | 435 (45.5) | |
| Exercise, little, n (%) | 833 (87.2) | NA |
| Fecal immunochemical test, n (%) | NA | 742a |
| Positive | 117 (15.8) | |
| Negative | 625 (84.2) | |
| Colorectal neoplasia, n (%) | 197 (20.6) | 383 (31.9) |
| Colorectal cancer, n (%) | 5 (0.5) | 10 (0.8) |
| Advanced neoplasia, n (%) | 39 (4.1) | 45 (3.7) |
NA Not applicable, SD Standard deviation, BMI Body mass index
aOnly 742 subjects in the validation set received the fecal immunochemical test due to practical factors