Fig. 1.

Association of SNP rs6677604 with mortality and cerebrospinal fluid FH concentration in patients with bacterial meningitis. In immunocompetent bacterial meningitis patients of Caucasian descent, the rs6677604 major allele G (minor allele frequency A EUR 0.187) was associated with an increased mortality under an additive model (a). P value was determined with the Pearson chi-square test. The rs6677604 major allele G was also associated with lower FH CSF levels under an additive model (b). P value was determined with the Kruskal-Wallis test. In bacterial meningitis patients the CSF FH concentration was significant higher compared to controls (c). Bacterial meningitis patients with an unfavorable outcome had slightly increased FH levels compared to patients with a favorable outcome. After correction for CSF total protein CSF FH levels were similar in bacterial meningitis patients with a unfavourable and a favourable outcome. P value was determined with the Mann-Whitney U test. Each dot represents an individual patient, gray dots represent deceased patients, lines represent median values and error bars are interquartile ranges