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. 2019 Dec 28;16:279. doi: 10.1186/s12974-019-1675-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Immunohistochemical staining of brain tissue of a pneumococcal meningitis patient.

In the pneumococcal meningitis FH was expressed in the brain parenchymal cells (a), with strong expression in Purkinje cells (a, asterisk) and in cells in the granular layer (a, arrows). In the control case the parenchyma was negative (b) and FH expression was confined in the blood within blood vessels (b, arrow). Inflammatory cells in the meninges of the pneumococcal meningitis case showed strong expression of FH (c) and macrophages show stronger positivity than granulocytes (c, arrowheads). In the control case, meningeal cells showed variable intensity FH expression (d, arrowheads)