Figure 5. ISG15 expression is induced in CRC tissue and in the adjacent stroma, but not in normal mucosa of the colon.

(A) ISG15 was immunolocalized in single cells and in small clusters of CRC cells in the tumor tissue in 51% of the samples (red arrows). (B) ISG15 was also detected in 44% of the CRC cases in the lumen (red arrows) of the colonic tumors and in the stroma (blue arrows). (C) ISG15 was detected in the whole tumor tissue in poorly differentiated areas of some cases (red arrows). (D) The normal colonic mucosa was not stained with antibody to ISG15. The bar represents 200 μm.