Table 2. List of prognostic microRNA signatures in breast cancer.
| miRNA signature | Breast cancer type | Detection method | Prognostic value | Role | Biological sample | References |
|---|---|---|---|---|---|---|
| miR-183-5p,
miR-194-5p, miR-1285-5p signature |
BC not
classified |
microarrays,
qRT-PCR |
potential
prognostic factor for OS in young breast cancer patients (age <35 years) |
miR-183-5p onco-miR
miR-194-5p onco-miR miR-1285-5p tumor suppressor |
FFPE | [48] |
| miR-21, miR-
30c, miR-181a, miR-181c, miR-125b, miR-7, miR- 200a, miR- 135b, miR-22 and miR-200c signature |
HR
positive, HER2 negative |
qRT-PCR | potential
prognostic factor for DRFS |
10-miRNA-based
classifier as a prognostic model |
FFPE | [49] |
| miR-155, miR-
493, miR-30e and miR-27a signature |
TNBC | qRT-PCR, IHC | potential
prognostic factor for OS associated with taxanes resistance |
miR-155 tumor
suppressor miR-493 tumor suppressor miR-30e onco-miR miR-27a onco-miR |
FFPE | [50] |
| miR-16, 155,
125b, 374a signature |
TNBC | qRT-PCR | potential
prognostic factor for OS |
miR-16 tumor
suppressor miR-155 tumor suppressor miR-125b onco-miR miR-374a tumor suppressor |
FFPE | [51] |
| miR-16, 125b,
374a, 374b, 421, 655, 497 signature |
TNBC | qRT-PCR | potential
prognostic factor for DDFS |
miR-16 tumor
suppressor miR-125b onco-miR miR-374a tumor suppressor miR-374b tumor suppressor miR-421 onco-miR miR-655 onco-miR miR-497 tumor suppressor |
FFPE | [51] |
| miR-191-5p,
miR-214-3p, miR-451a, and miR-489 signature |
BC not
classified |
qRT-PCR,
microarray |
independent
prognostic factor for OS, DFS |
miR-191-5p onco-miR
miR-214-3p tumor suppressor miR-451a tumor suppressor miR-489 tumor suppressor |
FFPE, cell lines | [52] |
Abbreviations: breast cancer (BC), quantitative reverse transcriptase real-time polymerase chain reaction (qRT-PCR), formalin-fixed paraffin embedded (FFPE), overall survival (OS), distant disease-free survival (DDFS), distant recurrence free survival (DRFS).