Table 1.
Biodistribution of 89Zr-SiR-LDFC-trastuzumab (n = 4) and 89Zr-DFO-trastuzumab (n = 5) at 96 h p.i. in Nude Mice Bearing SKOV-3 Xenografts
| biodistribution 96 h p.i. (% ID/g ± stdev) | ||
|---|---|---|
| 89Zr-SiR-LDFC-trastuzumab | 89Zr-DFO-trastuzumab | |
| blood | 1.77 ± 1.06 | 6.01 ± 4.01 |
| heart | 1.05 ± 0.48 | 2.23 ± 0.77 |
| lung | 1.71 ± 0.75 | 4.12 ± 1.58 |
| liver | 5.96 ± 1.96 | 14.0 ± 6.4 |
| spleen | 4.60 ± 1.67 | 5.33 ± 1.60 |
| kidney | 2.62 ± 1.60 | 3.40 ± 0.97 |
| small intestine | 0.89 ± 0.38 | 1.32 ± 0.29 |
| muscle | 0.41 ± 0.23 | 0.66 ± 0.27 |
| bone | 6.96 ± 5.65 | 1.83 ± 0.44 |
| tumor | 16.9 ± 9.2 | 20.7 ± 6.0 |