Table 2.
MIC50 and MIC90 of WCK 771 in Comparison to Metronidazole and Clindamycin in Different Anaerobes
| Bacteria | Anaerobes MIC (mg/L) | |||||
|---|---|---|---|---|---|---|
| WCK 771 | Metronidazole | Clindamycin | ||||
| MIC50 | MIC90 | MIC50 | MIC90 | MIC50 | MIC90 | |
| Bacteroides fragilis | 1 | 16 | 1 | 1 | 2 | 2 |
| B. fragilis group | 1 | 8 | 1 | 1 | 2 | >32 |
| Fusobacteria | 0.5 | 8 | ≤0.125 | 0.25 | 0.06 | 32 |
| Prevotella, Porphyromonas | 0.25 | 1 | 1 | 4 | ≤0.016 | 0.06 |
| Peptostreptococci | 0.5 | 1 | 0.5 | 2 | 0.125 | 1 |
| Propionibacteria | 0.125 | 0.125 | >16 | >16 | 0.06 | 0.125 |
| Clostridium perfringens | 0.06 | 0.25 | 1 | 1 | 0.5 | 2 |
| Clostridium difficile | 0.5 | 1 | 0.25 | 0.25 | 8 | >32 |
Note: Data From: Peric M, Jacobs MR, Appelbaum PC. Anti-anaerobic activity of a novel fluoroquinolone, WCK 771, compared to those of nine other agents. Antimicrob Agents Chemother. 2004;48(8):3188–3192.23