Table 6.
Comparison of Clinical Outcomes of Quartile-Count of Eosinophil Cohorts
| Variables | Overall | Absolute Count of Peripheral Blood Eosinophilf | |||||
|---|---|---|---|---|---|---|---|
| Groups | 1 | 2 | 3 | 4 | P value | ||
| Participants, n | 493 | 129 | 120 | 129 | 115 | ||
| Stay of hospital, median (IQR) | 11(9–14) | 12(10–14) | 10(8–14) | 11(8–13) | 10(9–13) | 0.002 | |
| ICU admission, n (%) | 6(1.2) | 5(1) | 0(0) | 0(0) | 1(0.2) | 0.01 | |
| Mortality, n (%) | 5(1) | 1(0.2) | 3(0.6) | 1(0.2) | 0(0) | 0.283* | |
| Comorbidity, n (%) | Cardiovascular disease | 371(75.3) | 103(79.8) | 91(75.8) | 97(75.2) | 80(69.6) | 0.325 |
| Ischemic heart disease | 73(14.8) | 15(11.6) | 20(16.7) | 19(14.7) | 19(16.5) | 0.663 | |
| Heart failure | 188(38.1) | 62(48.1) | 52(43.3) | 39(30.2) | 35(30.4) | 0.005 | |
| Hypertension | 207(42) | 50(38.8) | 52(43.3) | 57(44.2) | 48(41.7) | 0.824 | |
| Peripheral vascular disease | 63(12.8) | 18(14) | 11 (9.2) | 18 (14) | 16(13.9) | 0.613 | |
| Arrhythmia | 78(15.8) | 24(18.6) | 18(15) | 20(15.5) | 16(13.9) | 0.767 | |
| Diabetes | 81(16.4) | 20(15.5) | 25(20.8) | 21(16.3) | 15 (13) | 0.433 | |
| Bronchiectasis | 87(17.6) | 22(17.1) | 24(20) | 21(16.3) | 20(17.4) | 0.884 | |
| Respiratory failure | 215(43.6) | 72(55.8) | 52(43.3) | 48(37.2) | 43(37.4) | 0.008 | |
| Pulmonary heart disease | 203(41.2) | 67(51.9) | 54(45) | 44(34.1) | 38(33) | 0.005 | |
| Mechanical ventilation, n (%) | NIMV | 147(29.8) | 53(41.1) | 37(30.8) | 28(21.7) | 29(25.2) | 0.005 |
| IMV | 4(0.8) | 2(0.4) | 1(0.2) | 0(0) | 1(0.2) | 0.657* | |
| Duration of NIMV | 238(139.75–309.75) | 237(138.5–320) | 242.49(148.295)** | 242.71(116.665)** | 241(164.25–304.25) | 0.994 | |
Notes: fPatients were grouped by quartile absolute count (0, 0.05×109/L, 0.17×109/L) of blood eosinophils and divided into group 1, 2, 3 and 4 (from low to high).IQR, interquartile range: 25%–75%; *Fisher’s exact probability method; **Mean (SD, standard deviation).
Abbreviations: N, number; E%, percent of blood eosinophil in white blood cell; E, absolute count of peripheral blood eosinophil; ICU, intensive care unit; NIMV, noninvasive mechanical ventilation; IMV, invasive mechanical ventilation.