Table 1.
Trials Comparing Platelet Transfusion Approaches in Preterm Neonates
| Trial: | Andrew et al.(8) | Curley et al.(9**) | Kumar et al.(10) |
|---|---|---|---|
| Population | GA < 33 weeks, birthweight 500–1500 g, and platelets < 150 × 109/L (N=152) | GA < 34 weeks’ and platelets < 50 × 109/L (N=660) | GA < 35 weeks’, hemodynamically significant PDA and platelets < 100 × 109/L (N=44) |
| Intervention/Comparison | |||
| Higher platelet transfusion threshold | 150,000/μL | 50,000/μL | 100,000/μL |
| Lower platelet transfusion threshold | 50,000/μL or bleeding | 25,000/μL | 20,000/μLa |
| Outcome (primary) | New intracranial hemorrhage | Death or new major/ severe bleeding | Time to PDA closure |
| Time to follow-up for primary outcome | 7–10 days | 28 days after randomization | 120 hours after randomization |
| Summary of results for primary outcome | No difference 28% vs. 26%, P=0.73 |
Worse with higher platelet transfusion threshold OR 1.57 (95% CI 1.06–2.32), P=0.02 |
No difference Adjusted HR 1.4 (95% CI 0.57–3.47), P=0.46 |
Abbreviations: GA, gestational age; PDA, patent ductus arteriosus; OR, odds ratio; HR, hazard ratio
a
without surgery or bleeding