Table 2.

Platelet Transfusion Thresholds in Children

Indication	Platelet transfusion threshold
Bleeding	Dependent on degree and underlying reason for bleeding
Bleeding on ECMO or during surgery	50,000–100,000/μL
Prophylaxis for hypoproliferative thrombocytopenia	10,000/μL (15,000–20,000/μL for HSCT)
Prophylaxis for line placement	20,000/μL
Prophylaxis for lumbar puncture	50,000–100,000/μL (higher threshold considered when circulating blasts present)
Prophylaxis for CNS bleeding in children with sickle cell disease undergoing transplantation	30,000–50,000/μL
Prophylaxis for major surgery	50,000/μL (prophylaxis may be higher for CNS surgery)
Platelet dysfunction with bleeding and/or in need of an invasive procedure	Not applicable

Abbreviations: ECMO, extracorporeal membrane oxygenation; CNS, central nervous system; HSCT, hematopoetic stem cell transplantation.