TABLE 2.

Inhibitory role of oxidants during host inflammation

Agonist/model	Inflammatory response
LPS intra-tracheal instillation	1. Neutrophilic alveolitis; enhanced Nf-κB activation associate with aggravated lung injury in p47phox−/− mice.82,118  2. Decreased IL-10 production through attenuation of Akt-GSK3-β pathways in p47phox−/− mice.82
Zymosan intra-tracheal	Neutrophilic inflammation and augmented inflammatory cytokine production in p47phox−/− mice.119
Aspergillus fumigatus	1. Invasive Aspergillosis, neutrophilic inflammation and granulomas in gp91phox−/− mice.120  2. Defective autophagy resulting in augmented IL-1β production that worsens inflammation in p47phox−/− mice.121
Tobacco smoke exposure	Exacerbated inflammation and lung emphysema in oxidase null (gp91phox−/− and p47phox−/−) mice.122
Gram negative sepsis	Enhanced PMN alveolar transmigration and acute lung injury in oxidase null mice (gp91phox−/− and p47phox−/−).123
Systemic inflammatory response syndrome (SIRS)	Early mortality due to hyper-inflammation and advanced lung pathology in oxidase null mice (gp91phox−/−).84
Necrotic cells/DAMPs	Leukocytosis, neutrophilia and elevated tissue accrual of neutrophils that prolongs inflammation gp91phox−/− mice.79,80
Branched β-glucans	Skin granulomas.81,83
Collagen induced arthritis	Enhanced T cell autoreactivity, and development of severe arthritis.85,124
Influenza model	Increased inflammatory cell infiltration, Th1 driving cytokines in gp91phox−/− mice.125