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. Author manuscript; available in PMC: 2019 Dec 28.
Published in final edited form as: J Nutr Biochem. 2019 Feb 20;67:212–218. doi: 10.1016/j.jnutbio.2019.02.003

Table 1.

Diet, statin, and diet × statin interaction differentially expressed genes in EAT1

Gene Symbol Gene Name Diet effect Statin effect Diet × statin Average expression (rpkm)
FC FDR FC FDR FDR WD (n=7) WD + S(n=8) HHD (n=6) HHD + S(n=6)
CCL5 C-C motif chemokine 5 2.59 0.814 7.15 * 0.054 0.563 0.86 0.77 0.33 2.40
CTHRC1 Collagen triple helix repeat-containing protein 1 −2.21 0.735 −4.20 * 0.080 1.000 0.33 0.28 0.73 0.17
CXCL10 C-X-C motif chemokine 10 11.96 0.468 22.56 * 0.072 0.313 3.93 2.28 0.33 7.47
DDX60 ATP-dependent RNA helicase DDX60 5.65 0.352 6.48 * 0.077 1.000 1.35 1.56 0.24 1.57
Unknown 12 ENSSSCG000000145653 2.28 0.513 2.96 * 0.080 1.000 10.73 12.96 4.72 14.05
ETV7 Transcription factor ETV7 9.94 0.352 14.10 * 0.059 0.385 0.47 0.38 0.05 0.68
GBP1 Guanylate-binding protein 1 6.05 0.468 10.64 * 0.054 0.385 17.55 14.63 2.91 31.22
GBP6 Guanylate-binding protein 6 7.56 0.352 14.41 ** 0.025 0.167 2.54 1.99 0.33 4.90
IDO1 Indoleamine 2,3-dioxygenase 1 7.87 0.352 14.41 ** 0.028 0.064 * 0.31 0.16 0.04 0.57
IFIT3 Interferon-induced protein with tetratricopeptide 3.51 0.352 4.09 * 0.077 0.962 5.61 5.87 1.60 6.62
ISG12(A) Interferon alpha-inducible protein 27 3.65 0.493 5.91 * 0.054 0.925 24.95 28.38 6.82 40.66
MYL4 Myosin light chain 4 0.09 0.353 −8.99 0.460 0.002 ** 0.07 1.67 0.83 0.10
MYL7 Myosin light chain 7 0.12 0.473 −8.09 0.358 0.002 ** 0.07 1.19 0.55 0.06
NKL Antimicrobial peptide NK-lysin 4.63 0.618 12.14** 0.048 0.083 * 1.42 0.68 0.30 3.75
OAS1 2′−5′-oligoadenylate synthase 1 3.11 0.352 3.86** 0.028 0.791 12.58 14.62 4.07 15.82
OAS2 2′−5′-oligoadenylate synthase 2 3.27 0.473 5.17 ** 0.048 1.000 10.56 14.25 3.24 16.91
PTN Pleiotrophin −3.61 0.513 −10.88 ** 0.005 0.364 0.97 0.78 3.56 0.33
RSAD2 Radical S-adenosyl methionine domain-containing protein 2 12.27 ** 0.015 13.63 ** 0.005 0.313 3.10 3.72 0.25 3.49
SLPI Secretory leukocyte peptidase inhibitor 1.38 0.814 1.97 ** 0.041 0.318 5.32 4.75 3.86 7.70
UBD Ubiquitin D 3.2 0.605 6.00 ** 0.048 0.364 3.54 2.88 1.10 6.68
XAF1 XIAP associated factor 1 3.98 0.358 5.81 ** 0.041 0.840 3.80 4.55 0.96 5.63
*

FDR adjusted P<.1.

**

FDR adjusted P<.05.

1

EAT: epicardial adipose tissue, FC: fold change, rpkm: reads per kilobase per million mapped reads, HHD: Heart Healthy diet, WD: Western diet, HHD+S: Heart Healthy diet with atorvastatin, WD+S: Western diet with atorvastatin, Diet effect: WD relative to HHD, Statin effect: atorvastatin relative to no atorvastatin.

2

Unknown transcript.

3

Ensembl ID.