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. Author manuscript; available in PMC: 2019 Dec 28.
Published in final edited form as: J Nutr Biochem. 2019 Feb 20;67:212–218. doi: 10.1016/j.jnutbio.2019.02.003

Table 2.

Top biological pathways of EAT differentially expressed genes with a fold change of±1.51

Top pathways Activation Molecules FDR
Diet effect
 Interferon signaling Up IFIT1, IFIT3, IFITM1, IRF1, IRF9, MX1,OAS1, STAT1 0.007
 Neuropathic pain Signaling in dorsal horn neurons Up CAMK4, CAMK2B, FGFR3, FOS, GPR37, GRIN3A, GRM4, KCNH2, KL, PLCD4, PLCH1, PRKCB, PRKCZ 0.009
 Role of pattern recognition receptors in recognition of bacteria and viruses Up CASP1,CCL5, IL8, FGFR3, IFIH1, IL25, IRF7, KL, MAPK10, OAS1, OAS2, PRKCB, PRKCZ 0.027
Statin effect
 Interferon signaling Up IFI35, IFIT1, IFIT3, IFITM1, IRF1, IRF9, MX1,OAS1, SOCS1, STAT1, STAT2 <0.0001
 IL-8 signaling Down ANGPT2, CCND2, CR2, IL8, CYBB, BEK, FGFR3, FRS2, GNA13, TGAM, MMP9, MYL7, NCF2, PIK3C2G, PTGS2, RHOU 0.003
 Leukocyte extravasation signaling Down CLDN4, CLDN12, CLDN19, CXCL12, CYBB, EZR, BEK, FGFR3, FRS2, ITGAM, MMP9, MMP25, NCF1, NCF2, PIK3C2G, RASGRP1 0.004
1

EAT: epicardial adipose tissue, Diet effect: WD relative to HHD, HHD: Heart Healthy diet, WD: Western diet, Statin effect: atorvastatin relative to no atorvastatin.