Table 1.
Comparison between OMRF and Euroimmun antibody assays. All positives by OMRF were also positive by Euroimmun≥15. EBO=Euroimmun; OMRF=Oklahoma Medical Research Foundation; #=number, NA=not applicable given there were zero positive OJ results on OMRF.
Autoantibody (EUROIMMUN vs OMRF) | #of patients tested | #of OMRF positive | #of positives on EBO | Cut-off (>=15)/+ | #of positives on EBO | Cut-off (>=36)/++ | #of positives on EBO | Cut-off (>=71)/+++ | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sensitivity | Specificity | Kappa | Sensitivity | Specificity | Kappa | Sensitivity | Specificity | Kappa | ||||||
Jo1 | 281 | 29 | 31 | 96.6 | 98.6 | 0.93 | 27 | 89.7 | 99.6 | 0.92 | 24 | 79.3 | 99.6 | 0.85 |
Mi2 | 280 | 20 | ||||||||||||
Mi2a | 280 | 20 | 94.7 | 99.6 | 0.94 | 11 | 55.0 | 100.0 | 0.69 | 2 | 10.5 | 100.0 | 0.18 | |
Mi2b | 280 | 30 | 85.0 | 95.0 | 0.65 | 18 | 60.0 | 97.7 | 0.60 | 8 | 40.0 | 100.0 | 0.55 | |
Mi2a or Mi2b | 280 | 33 | 100.0 | 94.9 | 0.73 | 22 | 80.0 | 97.6 | 0.74 | 8 | 40.0 | 100.0 | 0.55 | |
M12a and Mi2b | 280 | 17 | 80.0 | 99.6 | 0.85 | 7 | 35.0 | 100.0 | 0.50 | 2 | 10.0 | 100.0 | 0.17 | |
SRP | 280 | 18 | 27 | 94.4 | 96.2 | 0.74 | 20 | 94.4 | 98.6 | 0.89 | 13 | 70.6 | 99.6 | 0.79 |
PM-Scl | 279 | 12 | ||||||||||||
PM75 | 279 | 26 | 83.3 | 94.0 | 0.50 | 13 | 75.0 | 98.5 | 0.71 | 7 | 58.3 | 100.0 | 0.73 | |
PM100 | 279 | 15 | 83.3 | 98.1 | 0.73 | 10 | 66.7 | 99.2 | 0.72 | 4 | 25.0 | 99.6 | 0.36 | |
PM75 or PM100 | 279 | 33 | 100.0 | 92.1 | 0.50 | 16 | 83.3 | 97.7 | 0.70 | 8 | 58.3 | 99.6 | 0.69 | |
PM75 and PM100 | 279 | 8 | 66.7 | 100.0 | 0.79 | 7 | 58.3 | 100.0 | 0.73 | 3 | 25.0 | 100.0 | 0.39 | |
PL7 | 280 | 5 | 15 | 100.0 | 96.4 | 0.49 | 9 | 100.0 | 98.5 | 0.71 | 5 | 100.0 | 100.0 | 1.00 |
PL12 | 281 | 3 | 7 | 100.0 | 98.6 | 0.59 | 4 | 100.0 | 99.6 | 0.86 | 4 | 100.0 | 99.6 | 0.86 |
Ku | 279 | 3 | 5 | 100.0 | 99.3 | 0.75 | 5 | 100.0 | 99.3 | 0.75 | 5 | 100.0 | 99.3 | 0.75 |
EJ | 281 | 2 | 3 | 100.0 | 99.6 | 0.80 | 2 | 100.0 | 100.0 | 1.00 | 2 | 100.0 | 100.0 | 1.00 |
OJ | 281 | 0 | 2 | NA | NA | NA | 0 | NA | NA | NA | 0 | NA | NA | NA |