Table 1.
Associations between synovial fluid biomarker concentrations and each of the scored posttraumatic MR- knee features (the degree of infrapatellar and suprapatellar fat pad abnormalities, the extent of effusion synovitis, the extent of synovial proliferation). Associations were assessed using partial correlation coefficients (rhopartial) from Spearman’s rank correlation with adjustments for age and gender.
| Synovial fluid biomarker | Degree of IPFP abnormality | Degree of SPFP abnormality | Degree of Effusion synovitis | Degree of Synovial proliferation | ||||
|---|---|---|---|---|---|---|---|---|
| rho partial | 95% CI | rho partial | 95% CI | rho partial | 95% CI | rho partial | 95% CI | |
| Inflammatory | ||||||||
| IL-1ra (pg/ml) | 0.00 | (−0.41,0.42) | 0.14 | (−0.30,0.53) | −0.23 | (−0.59,0.21) | −0.20 | (−0.66,0.36) |
| IL-1α (pg/ml) | −0.14 | (−0.53,0.30) | 0.24 | (−0.21,0.60) | −0.33 | (−0.66,0.12) | −0.24 | (−0.68,0.33) |
| IFN-γ (pg/ml) | 0.64 | (0.26,0.85) | 0.40 | (−0.04,0.71) | 0.02 | (−0.40,0.43) | 0.30 | (−0.27,0.72) |
| IL-10 (pg/ml) | 0.47 | (0.04,0.75) | 0.37 | (−0.07,0.69) | 0.01 | (−0.41,0.42) | −0.18 | (−0.64,0.38) |
| IL-6 (pg/ml) | 0.56 | (0.16,0.81) | 0.57 | (0.17,0.81) | 0.15 | (−0.28,0.54) | 0.25 | (−0.32,0.69) |
| IL-8 (pg/ml) | 0.49 | (0.06,0.76) | 0.20 | (−0.24,0.58) | 0.06 | (−0.37,0.46) | 0.23 | (−0.34,0.67) |
| TNF-α (pg/ml) | 0.55 | (0.14,0.80) | 0.37 | (−0.07,0.69) | 0.01 | (−0.41,0.43) | 0.05 | (−0.49,0.55) |
| Cartilage degradation | ||||||||
| CTXII (ng/ml) | −0.04 | (−0.45,0.38) | 0.27 | (−0.18,0.62) | 0.10 | (−0.33,0.49) | 0.25 | (−0.32,0.68) |
| COMP (ug/ml) | −0.19 | (−0.56,0.25) | −0.04 | (−0.45,0.38) | −0.09 | (−0.49,0.34) | 0.13 | (−0.42,0.61) |
| sGAG (ug/ml) | −0.24 | (−0.60,0.20) | −0.06 | (−0.47,0.36) | −0.05 | (−0.46,0.37) | −0.10 | (−0.59,0.44) |
| MMP-1 (pg/ml) | 0.57 | (0.17,0.81) | 0.24 | (−0.20,0.60) | 0.17 | (−0.27,0.55) | 0.19 | (−0.37,0.65) |
| MMP-3 (pg/ml) | 0.60 | (0.21,0.83) | 0.19 | (−0.25,0.57) | 0.30 | (−0.14,0.64) | 0.45 | (−0.12,0.80) |
| MMP-9 (pg/ml) | 0.03 | (−0.39,0.44) | 0.05 | (−0.38,0.45) | 0.24 | (−0.20,0.60) | −0.27 | (−0.70,0.31) |
| Collagen Type II synthesis | ||||||||
| CPII (ng/ml) | 0.34 | (−0.10,0.67) | 0.17 | (−0.27,0.55) | 0.23 | (−0.22,0.59) | 0.33 | (−0.25,0.73) |
SPFP=suprapatellar fat pad; IPFP=infrapatellar Hoffa’s fat pad; IL=interleukin; IFN=interferon; TNF=tumor necrosis factor; TSG=tumor necrosis factor-stimulated gene 6 protein; NTX=N-terminal telopeptide; nM BCE=nanomoles bone collagen equivalent; CTXII=C-terminal cross linked telopeptide type II collagen; COMP=cartilage oligomeric matrix protein; sGAG= sulfated glycosaminoglycan; MMP=matrix metalloproteinases; CP II=procollagen II C-peptide.