Table 4.
Associations between T1ρ and T2 values of knee cartilage and synovial fluid biomarkers of cartilage degeneration assessed by partial correlation coefficients (rho partial, ρ) obtained by Spearman’s rank correlation with adjustments for age and gender.
| Biomarkers of cartilage damage | Relaxation times of Cartilage T1ρ (ms) |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MFC | LFC | MT | LT | PAT | TRO | |||||||
| ρ | 95% CI | ρ | 95% CI | ρ | 95% CI | ρ | 95% CI | ρ | 95% CI | ρ | 95% CI | |
| CTXII | −0.02 | (−0.44,0.40) | 0.24 | (−0.20,0.60) | 0.19 | (−0.25,0.57) | 0.43 | (−0.01,0.73) | 0.25 | (−0.19,0.61) | 0.09 | (−0.34,0.49) |
| COMP | −0.03 | (−0.44,0.39) | 0.11 | (−0.32,0.51) | −0.28 | (−0.63,0.16) | −0.07 | (−0.48,0.35) | −0.05 | (−0.46,0.37) | −0.36 | (−0.68,0.09) |
| sGAG | 0.08 | (−0.34,0.48) | 0.37 | (−0.07,0.69) | 0.05 | (−0.38,0.45) | −0.05 | (−0.46,0.38) | 0.09 | (−0.34,0.49) | −0.10 | (−0.50,0.33) |
| MMP-1 | −0.03 | (−0.44,0.39) | 0.08 | (−0.35,0.48) | −0.07 | (−0.47,0.36) | 0.42 | (−0.01,0.72) | 0.33 | (−0.11,0.66) | 0.25 | (−0.19,0.61) |
| MMP-3 | −0.04 | (−0.45,0.39) | 0.09 | (−0.34,0.49) | −0.15 | (−0.54,0.29) | 0.35 | (−0.09,0.67) | 0.28 | (−0.16,0.63) | 0.21 | (−0.23,0.58) |
| MMP-9 | −0.26 | (−0.61,0.19) | −0.13 | (−0.52,0.31) | −0.24 | (−0.60,0.21) | −0.09 | (−0.49,0.34) | −0.38 | (−0.70,0.06) | −0.19 | (−0.56,0.25) |
| Relaxation times of Cartilage T2 (ms) |
||||||||||||
| MFC | LFC | MT | LT | PAT | TRO | |||||||
| ρ | 95% CI | ρ | 95% CI | ρ | 95% CI | ρ | 95% CI | ρ | 95% CI | ρ | 95% CI | |
| CTXII | 0.08 | (−0.34,0.48) | 0.15 | (−0.29,0.53) | −0.14 | (−0.53,0.29) | 0.25 | (−0.20,0.61) | 0.20 | (−0.24,0.57) | −0.04 | (−0.45,0.38) |
| COMP | 0.14 | (−0.30,0.53) | 0.18 | (−0.26,0.56) | −0.48 | (−0.76,−0.05) | −0.13 | (−0.52,0.30) | 0.01 | (−0.41,0.42) | −0.20 | (−0.57,0.24) |
| sGAG | 0.17 | (−0.27,0.55) | 0.25 | (−0.19,0.61) | −0.14 | (−0.53,0.29) | 0.02 | (−0.40,0.43) | 0.10 | (−0.34,0.49) | −0.22 | (−0.58,0.23) |
| MMP-1 | 0.15 | (−0.28,0.54) | 0.20 | (−0.24,0.57) | 0.30 | (−0.14,0.64) | 0.21 | (−0.23,0.58) | 0.36 | (−0.08,0.68) | 0.41 | (−0.03,0.71) |
| MMP-3 | 0.19 | (−0.25,0.57) | 0.25 | (−0.19,0.61) | 0.19 | (−0.25,0.57) | 0.26 | (−0.18,0.62) | 0.34 | (−0.10,0.67) | 0.37 | (−0.07,0.69) |
| MMP-9 | −0.18 | (−0.56,0.26) | 0.05 | (−0.38,0.46) | −0.02 | (−0.43,0.40) | −0.18 | (−0.56,0.25) | −0.05 | (−0.46,0.37) | −0.03 | (−0.44,0.39) |
CTXII=C-terminal cross linked telopeptide type II collagen; COMP=cartilage oligomeric matrix protein; sGAG=sulfated glycosaminoglycan; MMP=matrix metalloproteinases; MFC=medial femoral condyle; LFC=lateral femoral condyle; MT=medial tibia; LT=lateral tibia; PAT=patella; TRO=trochlea.