Table 1.
Regulation of Nur77/Nr4a1 in B cells
| Conclusion | Stimulus / perturbation | Pathway | Read-out | Cell type | Ref. |
|---|---|---|---|---|---|
| Does not modulate Nur77 at steady state in vivo |
CD40L−/− | CD40 | Nur77-eGFP | B cells | 24 |
| TLR7−/− | TLR7 | Nur77-eGFP | B cells | 24 | |
| Un93b13d/3d | TLR3/7/9 | Nur77-eGFP | B cells | 24 | |
| MyD88fl/flMB1Cre | MyD88 | Endogenous Nur77/Nr4a1 | PerC B1a cells, spleen | 24 | |
| Germ-free mice | MyD88/TRIF | Endogenous Nur77/Nr4a1 | Spl B cells, spleen | 24 | |
| Constit. active STAT5 | JAK/STAT | Nur77-eGFP | thymocytes | 21 | |
| Does not induce Nur77 in vitro |
BAFF | BAFFR | Nur77-eGFP | B cells | 15 |
| IL-4 | JAK/STAT | Nur77-eGFP | B cells | 24 | |
| IL-2, IL-15 | JAK/STAT | Nur77-eGFP | CD8 (IL-2, 15) CD4 (IL-2) |
159 | |
| CXCL12/SDF1 | CXCR4 | Nur77-eGFP | B cells | 24 | |
| Induces Nur77 in vitro | LPS | TLR4 / Rp150 | Nur77-eGFP | B cells | 15,24 |
| CpG | TLR9 | Nur77-eGFP | B cells | 15,24 | |
| PAM3CSK4 | TLR1/2 | Nur77-eGFP | B cells | 24 | |
| Anti-Igk; sHEL Ag | BCR | Nur77-eGFP | B cells | 15,24 | |
| Modulates Nur77 at steady state in vivo | IgHEL BCR Tg | Ag / BCR | Nur77-eGFP | B cells | 15,24 |
| IgHEL BCR Tg / sHEL | Ag / BCR | Nur77-eGFP | B cells | 15,24 | |
| Lyn−/− | BCR via ITIMs | Nur77-eGFP | B cells | 24 | |
| CD45 allelic series | BCR via SFKs | Nur77-eGFP | B cells | 15 |