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. 2019 Dec 14;2019:9705929. doi: 10.1155/2019/9705929

Figure 7.

Figure 7

Inhibition of miR-140 counteracted the antiarthritic effects of melatonin in surgically induced OA mice. After the destabilization of the medial meniscus (DMM) surgery, the sham-op and DMM-op mice were injected with melatonin (MT), negative control miRNA (antago miR-NC), or miRNA-140 antagomir (antago miR-140). (a) Representative images of histological (H&E and Safranin O/Fast Green) and immunohistochemical (COL II and COL I) staining of the medial femoral condyle in OA mice. Scale bar = 100 μm. (b) OARSI scores were calculated based on the Safranin O/Fast Green staining results. (c, d) The percentages of COL II-positive (c) or COL I-positive (d) chondrocytes were counted. In each section, the quantitative analyses were counted at three random regions and then averaged. Values are the mean ± S.E.M. of ten independent experiments (n = 10). Statistically significant differences are indicated by ## where p < 0.01 vs. the CTRL group and ∗∗ where p < 0.01 between the indicated groups.