Table 12.

Guinea pig efficacy studies of buprenorphine, NSAIDs and local analgesics

Analgesic	Dose (mg/kg)	Route	Test	Duration of action	Comments	Reference
Buprenorphine
	0.05	SC	RS	12-24 h	Dosed q12h for 72.	189
	1-5	SC	Pin prick		ED50 3.0 mg/kg; ED75 4-5 mg/kg at 30 min post administration	35
	0.3 SRzp	SC	RS	6 h		189
	0.48 SRag	SC	Lap, VF	Up to 96 h	No change in behavior compared with analgesia only group	163
	0.6 mmol	IM	PW	4 h		213
Carprofen	1	SC	Lap, VF	Ineffective	Pain indices 2-8 h postoperative that resolved by 24 h	49
	4	SC	Lap, VF	Partially effective	Dosed daily for 3 d. Pain indices 8 h postoperative that resolved by 24 h	163
Meloxicam	0.2	SC	Lap		Dosed daily for 2 d. Received local bupivacaine and/or lidocaine. No effect.	52

Lap = laparotomy; PW = paw withdrawal assay; RS = Randall-Selitto test; VF = von Frey test;