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. 2019 Dec 23;7:304. doi: 10.3389/fcell.2019.00304

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Copyright © 2019 Makowiecka, Malek, Mazurkiewicz, Mrówczyńska, Nowak and Mazur.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of Tβ4 on focal adhesions’ formation and its impact on melanoma progression. Increased TMSB4X expression is positively correlated with FAs size, cells’ invasion abilities and expression of EMT markers. On the other hand we observed negative correlation between TMSB4X expression and number of FAs, cell’s adhesion area and ability of studied cells to adhere to ECM (Matrigel^TM). Motility of cells with low expression of TMSB4X was more depended on Rac1 action than Rho/ROCK1 activity.