Table 1.

Associations between each analyte and peak DRS scores and postoperative change in NfL

	Association with peak DRS					Association with rise in NfL
Analyte	ΔR2	t-value	DF	P-value	Bonferroni	ΔR2	t-value	DF	P-value	Bonferroni
IL-1B	0.060	2.508	89	0.014	0.153	0.061	2.942	85	0.004	0.042
IL-1ra	0.024	0.888	89	0.377	1.000	0.057	1.876	85	0.064	0.640
IL-2	0.014	0.925	89	0.357	1.000	0.060	2.379	85	0.020	0.196
IL-4	0.014	1.051	89	0.296	1.000	0.022	1.277	85	0.205	1.000
IL-6	0.008	0.723	89	0.471	1.000	0.027	1.642	85	0.104	1.000
IL-8	0.208	4.422	89	<0.001	<0.001	0.222	5.427	85	<0.001	<0.001
IL-10	0.126	2.071	89	0.041	0.454	0.163	3.501	85	0.001	0.007
IL-12p70	0.002	0.276	89	0.783	1.000	0.034	0.986	85	0.327	1.000
MCP-1	0.069	2.529	89	0.013	0.145	0.063	2.264	85	0.026	0.261
TNFa	<0.001	0.172	89	0.864	1.000	0.037	1.543	85	0.127	1.000
NfL	0.199	3.408	85	0.001	0.011	-	-	-	-	-

Peak DRS or rise in NfL were regressed on each analyte, individually, while statistically controlling for age and sex. Effect sizes were quantified as ΔR², i.e. the proportion of the total variance in the outcome explained by this predictor.