Table 3.
Allele and genotype frequencies of five VDR gene polymorphisms of the participants.
| Caries-free group (n = 245) | Moderate caries risk group (n = 156) | High caries risk group (n = 148) | χ 2 | P | ||
|---|---|---|---|---|---|---|
| CdX-2 | A | 198 (40.4) | 138 (44.2) | 125 (42.5) | 1.177 | 0.555 |
| G | 292 (59.6) | 174 (55.8) | 169 (57.5) | |||
| AA/AG/GG | 37/124/84 (15.1/50.6/34.3) | 28/82/46 (17.9/52.6/29.5) | 31/63/53 (21.1/42.9/36.1)# | 4.648 | 0.325 | |
| Carriage of allele A | 161 (65.7) | 110 (70.5) | 94 (63.9) | 1.626 | 0.444 | |
|
| ||||||
| Fok I | C | 269 (54.9) | 166 (53.2) | 190 (64.2) | 8.952 | 0.011 |
| T | 221 (45.1) | 146 (46.8) | 106 (35.8) | |||
| CC/CT/TT | 75/119/51 (30.6/48.6/20.8) | 40/86/30 (25.6/55.1/19.2) | 58/74/16 (39.2/50.0/10.8) | 10.899 | 0.028 | |
| Carriage of allele C | 194 (79.2) | 126 (80.8) | 132 (89.2) | 6.715 | 0.035 | |
| Carriage of allele T | 170 (69.4) | 90 (60.8) | 116 (74.4) | 6.625 | 0.036 | |
|
| ||||||
| Taq I | C | 39 (8.0) | 14 (4.5) | 17 (5.7) | 4.191 | 0.123 |
| T | 449 (92.0) | 298 (95.5) | 279 (94.3) | |||
| CC/TT/TC | 1/37/206 (0.4/15.2/84.4)# | 0/14/142 (0.0/9.0/91.0) | 1/15/132 (0.7/10.1/89.2) | —∗ | 0.197 | |
| Carriage of allele C | 38 (15.6) | 14 (9.0) | 16 (10.8) | 4.289 | 0.117 | |
|
| ||||||
| Bsm I | A | 33 (6.7) | 12 (3.8) | 16 (5.4) | 3.049 | 0.218 |
| G | 457 (93.3) | 300 (96.2) | 280 (94.6) | |||
| AA/AG/GG | 1/31/213 (0.4/12.7/86.9) | 0/12/144 (0.0/7.7/92.3) | 0/16/132 (0.0/10.8/89.2) | —∗ | 0.401 | |
| Carriage of allele A | 32 (13.1) | 12 (7.7) | 16 (10.8) | 2.825 | 0.244 | |
|
| ||||||
| Apa I | A | 142 (29.1) | 78 (25.2) | 85 (28.7) | 1.603 | 0.449 |
| C | 346 (70.9) | 232 (74.8) | 211 (71.3) | |||
| AA/AC/CC | 21/100/123 (8.6/41.0/50.4)# | 9/60/86 (5.8/38.7/55.5)# | 8/69/71 (5.4/46.6/48.0) | 3.864 | 0.425 | |
| Carriage of allele A | 121 (49.6) | 69 (44.5) | 77 (52.0) | 1.816 | 0.403 | |
∗When cells had expected count <5, Fisher's exact test was used. #Using MGB-TaqMan® genotyping method, 1 subject in the high caries risk group had negative result of Cdx-2. 1 subject in the caries free group had negative result of Taq I. 1 subject in the caries-free group and 1 subject in the moderate caries risk group had negative result of Apa I.