Table 2.
Univariate and multivariate Cox proportional hazard models for OS.
| Overall survival (OS) | ||||
|---|---|---|---|---|
| Univariate | Multivariate | |||
| HR (95% CI) | p | HR (95% CI) | p | |
| Age | ||||
| ≤50y | 1 | |||
| >50y | 1.597 (0.870-2.931) | 0.131 | ||
| Grade | ||||
| I+II | 1 | |||
| III | 1.085 (0.572-2.057) | 0.802 | ||
| T stage | ||||
| T1 | 0.239 (0.088-0.644) | 0.005 | ||
| T2 | 0.424 (0.198-0.908) | 0.027 | ||
| T3 | 1 | |||
| N stage | ||||
| N0 | 0.272 (0.113-0.652) | 0.004 | ||
| N1 | 0.351 (0.136-0.907) | 0.031 | ||
| N2 | 0.466 (0.163-1.331) | 0.154 | ||
| N3 | 1 | |||
| AJCC stage | ||||
| I | 0.340 (0.126-0.916) | 0.033 | 0.466 (0.167-1.302) | 0.145 |
| II | 0.363 (0.189-0.699) | 0.002 | 0.458 (0.231-0.909) | 0.025 |
| III | 1 | 1 | ||
| HER-2 | ||||
| Negative | 1 | |||
| Positive | 1.300 (0.708-2.386) | 0.397 | ||
| ER | ||||
| Negative | 2.060 (1.104-3.844) | 0.023 | 1 | |
| Positive | 1 | 1.976 (1.020-3.829) | 0.044 | |
| PR | ||||
| Negative | 1.749 (0.898-3.407) | 0.1 | ||
| Positive | 1 | |||
| Types | ||||
| ER+ and/or PR+ | 1 | |||
| HER-2+/ER−/PR− | 1.902 (0.878-4.122) | 0.103 | ||
| HER-2−/ER−/PR− | 2.122 (1.055-4.269) | 0.035 | ||
| miR-362-5p | ||||
| Negative/weak | 1.873 (1.010-3.471) | 0.046 | ||
| Moderate/strong | 1 | |||
| Sema3A | ||||
| Negative/weak | 1 | 1 | ||
| Moderate | 4.716 (1.773-12.547) | 0.002 | 3.723 (1.221-11.353) | 0.021 |
| Strong | 3.619 (1.343-9.752) | 0.011 | 3.966 (1.333-11.803) | 0.013 |