Table 2.

Summary of the reported cases of IgG4-related hypophysitis.

Case no	Age	Sex	IgG4 (mg/dl)	Pituitary function		MRI		Number of other affected organs	Biopsy		Therapy	Response		Authors
				AH	DI	Stalk	Pituitary		Pituitary	Others		Symptom	MRI
1	66	F	485	+	−	−	+	4	−	—	GC	+	+	van der Vliet [3]
2	71	M	405	+	+	−	+	3	−	Submandibular gland, retroperitoneum	GC	+	+	Tanabe et al. [8]
3	70	M	2220	+	−	+	−	2	−	Submandibular gland	GC	+	+	Yamamoto et al. [9]
4	77	M	720	+	−	−	+	2	+	Pancreas, cholecyst	Surgery + GC	nd	nd	Wong et al. [5]
5	55	M	1860	+	+	+	−	2	−	Paranasal sinus	GC	+	+	Isaka et al. [10]
6	62	M	292	+	+	+	−	3	−	Lung	GC	+	+	Tsuboi et al. [11]
7	74	F	nd	+	+	+	+	1	+	—	Surgery + GC	+	+	Osawa et al. [12]
8	70	M	924	+	+	+	−	3	−	Liver, lung, parotid gland	GC	+	+	Hori et al. [14]
9	68	M	159	nd	+	+	+	2	−	—	GC	+	+	Haraguchi et al. [13]
10	74	F	170	+	+	+	+	1	−	Lymph node	GC	+	+	Haraguchi et al. [13]
11	55	M	127∗	+	+	+	+	3	−	Lacrimal gland, kidney	nd	nd	nd	Patel and Szostek [16]
12	71	M	240	−	+	+	+	1	−	Pleural	GC	nd	nd	Nagai et al. [15]
13	75	M	nd	+	+	+	+	1	+	Paranasal sinus	GC	+	+	Leporati et al. [6]
14	47	M	94.9	nd	nd	−	+	3	+	Lung, lymph node	GC	+	+	Nishina et al. [17]
15	53	F	Normal	+	−	−	+	0	+	—	Surgery + GC	+	+	Kanoke et al. [20]
16	60	F	Normal	+	−	+	+	0	+	—	Surgery + GC	+	+	Kanoke et al. [20]
17	66	M	nd	+	−	+	−	4	+	Mediastinum	Surgery + GC	+	+	Hsing et al. [19]
18	55	M	1010	−	−	+	+	0	+	—	GC	+	+	Hattori et al. [18]
19	53	M	24.5	+	+	+	−	3	−	Lung	GC	nd	+	Bando et al. [21]
20	76	M	513	+	+	+	+	0	−	—	GC	nd	+	Bando et al. [21]
21	58	F	405	nd	+	+	+	3	−	Lung, stomach	GC	nd	+	Bando et al. [21]
22	68	F	16.9	+	−	+	−	0	+	—	GC	nd	+	Bando et al. [21]
23	53	F	16.9	+	+	+	+	1	+	—	GC	nd	+	Bando et al. [21]
24	67	F	82.5	+	+	+	+	0	+	—	GC	nd	+	Bando et al. [21]
25	76	M	2100	+	+	+	+	2	+	Pancreas	GC	+	+	Iseda et al. [23]
26	33	F	nd	+	+	+	−	0	+	—	Surgery + GC	+	+	Khong et al. [24]
27	70	M	300	+	+	+	+	3	+	Retroperitoneum	GC	+	+	Ohkubo et al. [25]
28	40	M	413	+	+	+	+	1	+	Lacrimal gland	GC + azathioprine	+	+	Caputo et al. [22]
29	37	F	nd	+	+	+	+	0	+	—	GC	+	+	Sosa et al. [26]
30	25	F	nd	+	−	+	+	0	+	—	GC	+	+	Sosa et al. [26]
31	71	M	nd	−	+	+	+	0	+	—	nd	nd	nd	Imber et al. [28]
32	87	M	285	+	+	+	+	0	−	—	GC	+	+	Nakasone et al. [30]
33	32	F	nd	+	+	−	+	0	+	—	GC			Tauziede-Espariat et al. [32]
34	38	F	Normal	+	+	−	+	0	+	—	GC	+	+	Tauziede-Espariat et al. [32]
35	43	M	79.2	+	−	+	+	1	+	—	GC	+	−	Ngaosuwan et al. [31]
36	67	M	240	+	+	+	−	2	−	Liver	GC + azathioprine	+	+	Joshi et al. [29]
37	62	M	307	−	+	+	+	2	−	Kidney	GC	nd	nd	Joshi et al. [29]
38	72	M	853	+	+	+	−	1	−	Kidney	GC	+	+	Harano et al. [27]
39	38	F	377	+	+	−	+	2	+	Orbita	GC	+	+	Alexandraki et al. [33]
40	55	M	800	+	+	+	+	0	+	—	GC	+	+	Bhagwat et al. [34]
41	16	F	nd	−	+	+	+	0	+	—	GC	nd	nd	Decker et al. [35]
42	54	M	nd	+	+	+	+	2	−	Kidney	GC	+	+	Patel et al. [36]
43	76	M	1030	+	−	+	+	0	+	—	GC	+	+	Anno et al. [37]
44	57	M	83.9	+	+	+	+	5	+	—	GC + azathioprine	+	nd	Gu et al. [38]
45	29	F	135	+	+	−	+	0	+	—	Surgery + GC + MMF	+	+	Hadjigeorgiou et al. [39]
46	56	M	570.7	+	+	+	+	2	−	—	Surgery + GC	+	+	Huang et al. [40]
47	70	M	425	+	+	+	−	4	−	Lip	No	—	—	Kawasaki et al. [41]
48	51	F	nd	+	+	+	+	0	+	—	Surgery + GC	+	+	Lee et al. [42]
49	85	M	713	nd	+	+	−	1	−	Kidney	GC	+	+	Matsuda et al. [43]
50	36	F	nd	+	+	+	+	0	+	—	Surgery + GC	+	nd	Rotondo et al. [44]
51	49	M	nd	+	−	+	+	0	+	—	GC	+	+	Rotondo et al. [44]
52	56	M	298	+	−	+	+	3	−	—	GC	+	+	Yatabe et al. [45]
53	14	F	61	−	−	+	+	0	+	—	GC + rituximab	−	+	Bullock et al. [46]
54	25	F	55.7	+	+	+	+	0	+	—	GC	+	+	Koide et al. [48]
55	23	F	nd	+	+	−	+	1	+	Retroperitoneum	Surgery + GC	nd	nd	Guarda et al. [47]
56	50	M	426	+	+	−	+	7	+	—	GC	−	−	Liu et al. [49]
57	16	F	43.7	+	+	+	−	2	−	Submandibular gland	GC	−	−	Liu et al. [49]
58	57	F	2250	−	+	+	−	3	−	Lacrimal gland	GC	+	+	Liu et al. [49]
59	36	M	2470	−	+	+	−	4	−	Lacrimal gland	GC	+	+	Liu et al. [49]
60	44	M	1910	−	+	+	−	3	−	Pancreas	GC	+	+	Liu et al. [49]
61	46	M	327	+	+	+	−	1	−	Lymph node	GC	+	+	Liu et al. [49]
62	51	M	1980	−	+	+	−	3	−	Submandibular gland	GC	+	+	Liu et al. [49]
63	58	M	5410	+	+	+	−	4	−	—	GC	+	+	Liu et al. [49]
64	64	M	199	+	+	+	+	0	−	—	GC	+	+	Liu et al. [49]
65	61	M	4680	+	+	+	+	2	−	Paranasal sinus	GC	+	+	Liu et al. [49]
66	58	F	58	+	+	+	+	0	+	—	GC	+	+	Murphy et al. [50]
67	36	M	Normal	+	+	+	+	0	+	—	GC	+	+	Sosa et al. [51]
68	67	F	865	nd	+	+	−	6	+	Bladder	GC	+	+	Xue et al. [53]
69	50	M	13.1	nd	nd	−	+	0	+	—	Surgery	+	+	Tang et al. [52]
70	24	F	Normal	+	+	+	+	0	+	—	Surgery + GC	+	+	Yuen et al. [54]
71	24	F	Normal	nd	nd	−	+	0	+	—	GC	+	nd	Yuen et al. [54]
72	71	M	Normal	+	+	−	+	0	+	—	GC	+	−	Yuen et al. [54]
73	78	M	802	+	nd	−	+	4	−	—	Surgery + GC	+	+	Kanie et al. [56]
74	43	F	462	+	+	+	+	2	−	Orbita	GC	+	+	Yoshida et al. [58]
75	28	F	880	−	−	−	+	0	−	—	Methotrexate + rituximab	+	nd	Goulam-Houssein et al. [55]
76	65	M	221	+	nd	−	+	0	+	—	Surgery + GC + rituximab	+	+	Vauchot et al. [57]

F, female; M, male; nd, not described; AH, anterior hypophysitis; DI, diabetes insipidus; GC, glucocorticoid; MMF, mycophenolate mofetil.