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. 2019 Dec 12;7(1):e645. doi: 10.1212/NXI.0000000000000645

Figure 2. Effect of SHP2 inhibition in DOK7-overexpressing C2C12s.

Figure 2

(A) MuSK phosphorylation was already high in DOK7-overexpressing C2C12s (data not shown) but was increased further by NSC-87877. (B) Equally DOK7-overexpressing myotubes showed AChR clusters that were further increased by NSC-87877. All images are 20× magnification. Scale bar represents 50 µm. Results were analyzed by 2-sided t tests. DOK7 = downstream of kinase 7; MuSK = muscle-specific kinase; SHP = SRC homology 2 domain-containing phosphotyrosine phosphatase 2.