TABLE 4.
PCR-based assay performance compared to histopathology
| Parameter | PCR results for specimens from sites with: |
|
|---|---|---|
| Any histopathologya (n = 95) | Angioinvasion (n = 48) | |
| Sensitivity [% (95% CIb )] | 63.2 (52.6–72.8) | 83.3 (69.8–92.5) |
| Specificity [% (95% CI)] | 99.2 (95.4–99.9) | 99.2 (95.4–99.9) |
| Positive predictive value [% (95% CI)] | 98.4 (89.4–99.8) | 97.6 (85.0–99.7) |
| Negative predictive value [% (95% CI)] | 77.0 (72.0–81.3) | 93.6 (88.6–96.5) |
| False-positive rate (%) | 0.8 | 0.8 |
| False-negative rate (%) | 36.8 | 16.7 |
| Positive likelihood ratio | 75.8 | 98.3 |
| Negative likelihood ratio | 0.37 | 0.17 |
a
Includes both angioinvasion and nonvascular-tissue invasion.
b
CI, confidence interval.