TABLE 4.
Key divergent loci for strains clustered together by the three-gene schemea
| MAB or MMA ST | Locus no. |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| hsp65 | rpoB | secA | argH | cya | glpK | gnd | murC | pta | purH | gdhA | pgm | pknA | |
| MAB1 ST1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 7 | 2 | 6 |
| MAB5 ST1 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 7 | 2 | 6 |
| MAB1 ST22 | 1 | 1 | 1 | 3 | 1 | 1 | 3 | 5 | 15 | 1 | 15 | 7 | 7 |
| MAB1 ST40 | 1 | 1 | 1 | 3 | 11 | 1 | 3 | 3 | 18 | 3 | 11 | 9 | 8 |
| MAB1 ST63 | 1 | 1 | 1 | 3 | 11 | 1 | 3 | 3 | 3 | 3 | 11 | 5 | 8 |
| MAB1 ST127 | 1 | 1 | 1 | 3 | 23 | 1 | 3 | 3 | 3 | 3 | 11 | 5 | 8 |
| MAB1 ST276 | 1 | 1 | 1 | 3 | 1 | 1 | 3 | 3 | 12 | 35 | 10 | 5 | 7 |
| MAB1 ST280 | 1 | 1 | 1 | 3 | 14 | 7 | 3 | 3 | 6 | 36 | 11 | 5 | 8 |
| MAB1 ST272 | 1 | 1 | 1 | 18 | 1 | 1 | 8 | 5 | 1 | 1 | 11 | 2 | 7 |
| MAB1 ST289 | 1 | 1 | 1 | 18 | 32 | 1 | 3 | 5 | 1 | 1 | 17 | 9 | 7 |
| MAB1 ST277 | 1 | 1 | 1 | 20 | 12 | 1 | 8 | 3 | 37 | 9 | 16 | 2 | 7 |
| MAB1 ST283 | 1 | 1 | 1 | 18 | 32 | 1 | 1 | 5 | 1 | 1 | 17 | 9 | 7 |
| MAB1 ST284 | 1 | 1 | 1 | 3 | 11 | 1 | 3 | 3 | 3 | 20 | 11 | 5 | 8 |
| MAB1 ST288 | 1 | 1 | 1 | 3 | 11 | 1 | 3 | 3 | 32 | 3 | 11 | 5 | 8 |
| MAB3 ST33 | 1 | 1 | 2 | 7 | 5 | 1 | 8 | 5 | 6 | 1 | 10 | 6 | 7 |
| MAB3 ST49 | 1 | 1 | 2 | 3 | 11 | 1 | 3 | 3 | 5 | 10 | 11 | 8 | 8 |
| MAB3 ST286 | 1 | 1 | 2 | 38 | 1 | 1 | 3 | 5 | 1 | 1 | 12 | 7 | 7 |
| MAB4 ST137 | 1 | 2 | 2 | 3 | 12 | 1 | 3 | 5 | 1 | 10 | 9 | 2 | 7 |
| MAB4 ST278 | 1 | 2 | 2 | 13 | 12 | 1 | 3 | 3 | 3 | 9 | 11 | 7 | 7 |
| MMA2 ST117 | m1 | m2 | m2 | 11 | 14 | 4 | 24 | 6 | 2 | 16 | 2 | 1 | 1 |
| MMA2 ST275 | m1 | m2 | m2 | 11 | 14 | 30 | 24 | 6 | 2 | 16 | 2 | 1 | 1 |
| MMA5 ST176 | m2 | m4 | m1 | 21 | 13 | 4 | 10 | 6 | 11 | 7 | 4 | 1 | 3 |
| MMA5 ST287 | m2 | m4 | m1 | 21 | 13 | 4 | 10 | 8 | 11 | 7 | 4 | 1 | 3 |
| MMA6 ST115 | m1 | m4 | m2 | 24 | 20 | 1 | 9 | 8 | 8 | 27 | 3 | 2 | 2 |
| MMA6 ST285 | m1 | m4 | m2 | 24 | 20 | 1 | 9 | 6 | 8 | 27 | 3 | 2 | 2 |
| MMA9 ST273 | m1 | 1 | m2 | 11 | 20 | 1 | 9 | 8 | 8 | 27 | 3 | 2 | 2 |
| MMA11 ST273a | 1 | m4 | m2 | 11 | 20 | 1 | 9 | 8 | 8 | 27 | 3 | 2 | 1 |
a
The maximum sequence divergence observed in the pta, purH, and gdhA genes for M. abscessus subsp. abscessus and in the murC, purH, and gdhA genes for M. abscessus subsp. massiliense. The least sequence divergence was observed in the glpK gene for M. abscessus subsp. abscessus and in the argH, cya, and pgm genes for M. abscessus subsp. massiliense. A lowercase “m”—e.g., m1, m2, m2, m4, etc.—denotes allelic type numbering for M. abscessus subsp. massiliense.