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. 2019 Dec 23;10:2891. doi: 10.3389/fimmu.2019.02891

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Copyright © 2019 Serrano, Morán, Martinez-Flores, Mancebo, Pleguezuelo, Cabrera-Marante, Delgado and Serrano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Incidence of TRB-D (thrombotic events or death) in the first 3 months after heart transplantation. Red: Group-1. Blue: Group-2. Dark: Group-0. (A) Considering all the patients, the incidence was significantly higher in Group-1 vs. Group-0 (HR: 6.29; 95% CI: 2.22–12.79) and also in Group-2 vs. Group-0 (HR: 2.64; 95% CI: 1.15–6.07). (B) In patients without post-transplant risk factors for thrombosis, the incidence of TRB-D in the first trimester was significantly higher in Group-1 patients (B2A-CIC positive) vs. patients of Group-0 (HR 9.03; 95% CI: 1.28–63.65). No significant differences were observed between patients in Group-2 and those in Group-0 (HR: 1.46; 95% CI: 0.35–6.05). (C) In patients with risk factors for thrombosis, a significant higher incidence of TRB-D in Group-1 vs. Group-0 (HR: 3.27; 95% CI: 1.11–9.64) can also be observed. No significant differences were found between Group-2 vs. Group-0 (HR: 2.43; 95% CI: 0.92–6.43) and between Group-1 and Group-2 (HR: 1.30; 95% CI: 0.37–4.59).