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. 2019 Dec 23;7:342. doi: 10.3389/fcell.2019.00342

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Copyright © 2019 Gao, Zhang, Wei, Dai, Zhang, Yang, Li and Bai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neurogenic differentiation derived from amniotic epithelial cells (AECs). AECs were induced with all-trans retinoic acid (ATRA) for 18 days. (A,B) Neurogenic markers were detected by immunofluorescence staining and flow cytometry. Neuron-specific genes (β III-tubulin) and astrocyte-specific genes (glial fibrillary acidic protein: GFAP) were detected. Scale bar = 100 μm. (C–E) RT-qPCR was used to determine the relative expression of β III-tubulin, GFAP, and miR-128-3p in non-induced AECs and induced AECs. (F,G) Comparative analysis of miR-128-3p and β III-tubulin or GFAP in neurogenic differentiation. (H) The expression of Jagged 1 (JAG1), a putative target for miR-128-3p in neurogenic differentiation, was significantly altered in induced AECs. ^∗P < 0.05.