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. 2019 Dec 23;7:342. doi: 10.3389/fcell.2019.00342

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Copyright © 2019 Gao, Zhang, Wei, Dai, Zhang, Yang, Li and Bai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HES5 promotes transcription of the neurocyte marker genes β III-tubulin, NSE, and PSA-NCAM via physical interactions with their promoters. (A) HES5 promoter-binding sites were predicted using bioinformatics algorithms in the promoter region of β III-tubulin, NSE, and PSA-NCAM. Predicted sequences were calculated according to the relative frequency of promotor sequences, which have the potential to bind Hes 5 but do not completely conform to the sequence logo of Hes 5. Consensus sequences are shown in red. (B–D) The amount of HES5 enriched within neurocyte marker gene promoter regions in normal and induced AECs was quantified by ChIP-coupled real-time PCR. The percentage of input was calculated according to threshold cycle values. The negative control for Hes 5 binding sites is shown in the Supplementary Material. Data are presented as the mean ± SD (three independent experiments).