Table 4.

Results of published studies on the association between six genes and ischemic stroke in Morocco

Study	Cases	Controls	Genes	Mutations	Genotypes	Methods	Odds Ratio 95% (CI)	P value
They, TP et al., 2011 [40]	91	182	MTHFR	C677T	T allele and Stroke	PCR	1.1 (0.59–2.04)	0.303Ω
					T allele and atherothrombotic subtype stroke		2.1 (1.17–3.8)	0.012Ω
They, TP et al., 2013 [41]	91	182	MTHFR* F2	C677T G20210A	677TT/CC 20210GA/GG	PCR-RFLP	4.99 (1.75–14.2) 5.29 (1.63–17.1)	0.001∏ 0.005∑
Diakite, B et al., 2014 [39]	165	182	eNOS	G894 T	TT vs. GG + GT Recessive	PCR-RFLP	2,68 (1,08-6,70)	0.034 Δ
					GT + TT vs. GG Dominant		1.78 (1,16–2,73)	0.009 Δ
					T vs. G Additive models		1.71 (1,21–2,43)	0.003 Δ
Diakite, B et al., 2015 [37]	170	211	FV	C2491T	T allèle	PCR-RFLP	3.77 (2.70–5.25)	< 0.0001**
					CT		4.08 (2.55–6.49)
					TT		8.95 (4.15–19.29)
Diakite, B et al., 2016 [38]	175	201	APOA5	T1131C	CC	PCR-RFLP	2.86 (1.24–6.58)	0.014 ⋿
					C allele		1.54 (1.01–2.33)
			ALOX5AP	SG13S114	TT	PCR-RFLP	2.57 (1.49–4.83)	0.009 ⋿
					T allele		1.59 (1.16–2.19)	0.008 ⋿
Balar, K et al., 2014 [36]	165†		MTHFR	Facteurs de risque ‡	CT/TT	–	–	NS ^

PCR-RFLP Polymerase Chain Reaction-Restriction Fragment Length Polymorphism, ^*Synergistic effect of MTHFR C677T and F2 G20210A polymorphisms on ischemic stroke. ^†Prospective study, ^‡Age/Diabetes/High Blood Pressure/Smoking/Alcoholism/ Cholesterol, NS: Not significant, ^ΩHardy– Weinberg equilibrium tests were performed for MTHFR C677T polymorphism separately among cases and controls with the use of Fisher’s exact test, ^∏Univariate analysis for the combined polymorphisms, ^∑multivariate analysis for the combined polymorphisms, ^ΔThe law of the genotype distribution for G894 T eNOS polymorphism among disease cases and controls were performed with Hardy–Weinberg equilibrium test with the use of χ2 test, ^**Significant; HWE, Hardy–Weinberg equilibrium, ^⋿Hardy–Weinberg equilibrium test with the use of χ2 test or Fisher test, ^the multivariate analysis (logistic regression)