Table 2.
Genotype and allele distributions in Atrial fibrillation patients and controls
| Variant | Allele | Group | n | Genotype (frequency) | p | OR (95% CI), p | Allele (frequency) | OR (95%CI), p | Hardy-Weinberg equilibrium | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1/2 | 1/1 | 1/2 | 2/2 | 1/1 + 1/2vs 2/2 | 1 | 2 | 1 vs 2 | χ2 | p | ||||
| rs1956921 | C/T | AF | 126 | 2 (1.59%) | 25 (19.84%) | 99 (78.57%) | 0.285 | 0.629 (0.353–1.212) 0.114 | 29 (11.51%) | 223 (88.49%) | 0.664 (0.396–1.113) 0.118 | 0.084 | 0.7719 |
| controls | 119 | 3 (2.52%) | 33 (27.73%) | 83 (69.75%) | 39 (16.39%) | 199 (83.61%) | 0.017 | 0.8960 | |||||
| rs1800875 | A/G | AF | 124 | 10 (8.06%) | 38 (30.65%) | 76 (81.29%) | 0.009 | 0.500 (0.300–0.832) 0.007 | 58 (23.39%) | 190 (76.61%) | 0.685 (0.458–1.023) 0.064 | 2.601 | 0.1068 |
| controls | 120 | 7 (5.83%) | 60 (50.00%) | 53 (44.17%) | 74 (30.83%) | 166 (69.17%) | 3.561 | 0.0592 | |||||
| rs1800876 | T/C | AF | 119 | 23 (19.33%) | 59 (49.58%) | 37 (31.09%) | 0.082 | 1.122 (0.652–1.932) 0.678 | 105 (44.12%) | 133 (55.88%) | 1.298 (0.900–1.872) 0.162 | 5.502 | 0.0190 |
| controls | 119 | 11 (9.24%) | 68 (57.14%) | 40 (33.62%) | 90 (37.82%) | 148 (62.18%) | 0.036 | 0.9520 | |||||
| sc5244 | C/T | AF | 126 | 11 (8.73%) | 44 (34.92%) | 71 (56.35%) | 0.225 | 0.859 (0.518–1.426) 0.557 | 66 (26.19%) | 186 (73.81%) | 1.017 (0.677–1.527) 0.934 | 1.180 | 0.2774 |
| controls | 116 | 5 (4.31%) | 50 (43.10%) | 61 (52.59%) | 60 (25.86%) | 172 (74.14%) | 1.785 | 0.1816 | |||||
| rs1885108 | A/G | AF | 126 | 16 (12.70%) | 60 (47.62%) | 50 (39.68%) | 0.471 | 0.732 (0.434–1.234) 0.241 | 92 (36.51%) | 160 (63.49%) | 0.805 (0.560–1.157) 0.241 | 0.093 | 0.7603 |
| controls | 120 | 19 (15.83%) | 62 (51.67%) | 39 (32.50%) | 100 (41.67%) | 140 (58.33%) | 0.474 | 0.4911 | |||||
CI Confidence interval, OR Odds ratio. The minor allele was referred to as allele 1 and the major allele as allele 2. OR estimated by two-tailed P values and 95% confidence intervals (95% CI)