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. 2019 Dec 30;17:431. doi: 10.1186/s12967-019-02181-2

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© The Author(s) 2019

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The effects of ITGB1on the proliferation curve of TC ^ITGB1+ treated with PI3K inhibitors and TGFβ1. a–c Representative photos of TCs cultured for 0 h, 24 h and 48 h captured by celliq, respectively. d–f representative photos of TCs treated within TGFβ1 for 0 h, 24 h and 48 h, respectively. Arrows show typical TCs with long and thin telopodes with dilations. Original magnification ×100. g Analysis of TC ^ITGB1+ or TC^ITGB1− proliferation with the treatment of HS173 and TGFβ1. h Analysis of TC ^ITGB1+ or TC^ITGB1− proliferation with the treatment of GDC0941 and TGFβ1. i Analysis of TC ^ITGB1+ or TC^ITGB1− proliferation with the treatment of Enzastaurin and TGFβ1. j Analysis of TC ^ITGB1+ or TC^ITGB1− proliferation with the treatment of SB216763 and TGFβ1, n = 6–8, **stand for p values less than 0.05, as compared with TC ^ITGB1+ treated with TGFβ1