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. 2019 Dec 30;17:431. doi: 10.1186/s12967-019-02181-2

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© The Author(s) 2019

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — The effects of ITGB1 on cell cycle of TCs treated with PI3K inhibitors and TGFβ1. a–d Cell cycle analysis of HS173 (PI3K/p110α inhibitor) in TGFβ1-induced TC^ITGB1+ by flowcytometry. e–f. Cell cycle analysis of GDC0941 (pan-PI3K inhibitor) in TGFβ1-induced TC^ITGB1+ by flowcytometry. g–h Cell cycle analysis of Enzastaurin (PI3K/PKC inhibitor) in TGFβ1-induced TC^ITGB1+ by flowcytometry. i–j Cell cycle analysis of SB216763 (GSK-3 inhibitor) in TGFβ1-induced TC^ITGB1+ by flowcytometry, n = 3–6, * stand for p values less than 0.05, as compared with TGFβ1-induced TC ^ITGB1+, ^# stand for p values less than 0.05, as TC^ITGB1− treated with PI3K inhibitors and TGFβ1compared with TC ^ITGB1+ treated with PI3K inhibitors and TGFβ1. ** stand for p values less than 0.05, as compared with TC ^ITGB1+, ^## stand for p values less than 0.05, as compared with TC ^ITGB1−, ***stand for p values less than 0.05, as compared with TGFβ1-induced TC ^ITGB1+

Fig. 7 — The effects of ITGB1 on cell cycle of TCs treated with PI3K inhibitors and TGFβ1. a–d Cell cycle analysis of HS173 (PI3K/p110α inhibitor) in TGFβ1-induced TC^ITGB1+ by flowcytometry. e–f. Cell cycle analysis of GDC0941 (pan-PI3K inhibitor) in TGFβ1-induced TC^ITGB1+ by flowcytometry. g–h Cell cycle analysis of Enzastaurin (PI3K/PKC inhibitor) in TGFβ1-induced TC^ITGB1+ by flowcytometry. i–j Cell cycle analysis of SB216763 (GSK-3 inhibitor) in TGFβ1-induced TC^ITGB1+ by flowcytometry, n = 3–6, * stand for p values less than 0.05, as compared with TGFβ1-induced TC ^ITGB1+, ^# stand for p values less than 0.05, as TC^ITGB1− treated with PI3K inhibitors and TGFβ1compared with TC ^ITGB1+ treated with PI3K inhibitors and TGFβ1. ** stand for p values less than 0.05, as compared with TC ^ITGB1+, ^## stand for p values less than 0.05, as compared with TC ^ITGB1−, ***stand for p values less than 0.05, as compared with TGFβ1-induced TC ^ITGB1+