Table 2.

Significant two-locus and three-locus combinations identified by HiSSI on WTCCC BC data

Significant Interaction	Chromosome and Related Genes	Single-Locusp-Value	Interactionp-Value
(rs1108842, rs2289247)	(chr3: GNL3, chr3: GNL3)	(1.139×10−2,5.981×10−1)	6.048×10−45
(rs1130643, rs10017772)	(chr4: SPARCL1, chr4: DCHS2)	(2.823×10−1,3.830×10−1)	2.865×10−8
(rs3761967, rs715748)	(chr5: BDP1, chr5: BDP1)	(1.720×10−1,4.073×10−1)	1.238×10−54
(rs2242665, rs2856705)	(chr6: SLC44A4, chr6: *)	(3.484×10−4,6.178×10−8)	4.369×10−25
(rs1801197, rs6971091)	(chr7: CALCR, chr7: FAM71F1)	(4.983×10−2,6.728×10−1)	2.504×10−10
(rs365990, rs7158731)	(chr14: MYH6, chr14: ZNF839)	(8.807×10−3,3.319×10−3)	1.636×10−6
(rs8059973, rs3785181)	(chr16: DBNDD1, chr16: GAS11)	(3.019×10−4,1.464×10−3)	4.050×10−7
(rs2822558, rs2822787)	(chr21: ABCC13, chr21: SAMSN1-AS1)	(6.630×10−3,1.662×10−1)	4.207×10−21
(rs879882, rs2523608, rs805262)	(chr6: POU5F1, chr6: HLA-B, chr6: BAG6)	(2.711×10−1,7.096×10−1,5.836×10−4)	1.030×10−11

^*Indicates that the related gene is unknown.