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. 2019 Dec 30;20(Suppl 22):717. doi: 10.1186/s12859-019-3230-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Flowchart of the proposed computational framework. (1) Preprocessing of regulation pairs and expression profiles (2) Construction of disease-specific regulatory networks (3) Identification of 3-node FFLs (4) Construction of disease-specific co-expression networks (5) Prioritization of candidate molecules