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. 2019 Dec 30;38:506. doi: 10.1186/s13046-019-1483-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Knockdown of circNFIX induces cell cycle arrest and apoptosis and inhibits glycolysis, migration and invasion in glioma cells. (a) qRT-PCR assay determined the transfection efficacy in T98 and U251 cells after transfection of si-circNFIX or si-NC. Cell cycle distribution (b and c), glucose consumption (d), lactate production (e), HK2 protein level (f), migration (g), invasion (h) and apoptosis (i) were determined in T98 and U251 cells transfected with si-circNFIX or si-NC. Mock is non-transfected group. **P < 0.01, ***P < 0.001 compared with si-NC group