Table 3.

Interaction between age and comorbidities for all-cause mortality or all-cause hospitalization

Comorbidity	HR represents	Age-adjusted HR# (95% CI)	Age-comorbidity Interaction p-value
Body Mass Index		Refer to Figure 1	0.10
Atrial Fibrillation / Atrial Flutter	Yes vs. No	≤60 y: 1.50 (1.24 – 1.82) 60–69 y: 1.32 (1.06–1.63) ≥70 y: 1.21 (0.98 – 1.49)	0.07
Ischemic Heart Disease	Yes vs. No	1.15 (1.03 – 1.27)	0.63
Hypertension (History)	Yes vs. No	1.21 (1.09 – 1.34)	0.19
Peripheral Vascular Disease	Yes vs. No	1.41 (1.17 – 1.70)	0.34
Diabetes (History)	Yes vs. No	1.25 (1.13 – 1.39)	0.13
COPD	Yes vs. No	1.28 (1.10 – 1.48)	0.59
Anemia	Yes vs. No	1.40 (1.23 – 1.58)	0.61
eGFR (truncated at 90)	5 unit decrease	1.05 (1.03 – 1.06)	0.83
Beck Depression Inventory	5 unit increase	1.09 (1.06 – 1.12)	0.34
Comorbidity score	Per comorbidity	1.18 (1.14–1.22)	0.50

^#Hazard ratio adjusted for age. Age truncated from below at 60 years.