Table 4.

Interaction between age and comorbidities for all-cause mortality

Comorbidity	HR represents	Age-adjusted HR# (95% CI)	Age-comorbidity Interaction p-value
Body Mass Index		Refer to Figure 1C	0.03
Atrial Fibrillation / Atrial Flutter	Yes vs. No	1.68 (1.34 – 2.09)	0.23
Ischemic Heart Disease	Yes vs. No	1.16 (0.94 – 1.43)	0.63
Hypertension (History)	Yes vs. No	<60 y: 1.05 (0.76 – 1.45) 60–69 y: 1.02 (0.67 – 1.53) ≥70 y: 0.77 (0.53 – 1.10)	0.10
Peripheral Vascular Disease	Yes vs. No	1.75 (1.28 – 2.41)	0.37
Diabetes (History)	Yes vs. No	1.32 (1.08 – 1.62)	0.56
COPD	Yes vs. No	1.73 (1.32 – 2.26)	0.39
Anemia	Yes vs. No	1.39 (1.10 – 1.76)	0.79
eGFR (truncated at 90)	5 unit decrease	1.10 (1.07 – 1.13)	0.20
Beck Depression Inventory	5 unit increase	<60 y: 1.05 (0.97 – 1.13) 60–69 y: 1.08 (0.97 – 1.20) ≥70 y: 1.27 (1.12 – 1.43)	0.03
Comorbidity score	Per comorbidity	1.21 (1.13–1.30)	0.30

^#Hazard ratio for each comorbidity adjusted for age. Age truncated from below at 60 years.