Skip to main content
. Author manuscript; available in PMC: 2020 Mar 29.
Published in final edited form as: J Mol Biol. 2019 Feb 22;431(7):1380–1396. doi: 10.1016/j.jmb.2019.02.014

Figure 5.

Figure 5

VWF extension slightly depends on pH from 6.2 to 9.8. VWF multimer extension normalized to length during the first 1280 dyn cm−2 flow (L0, color key) vs. wall shear stress under forward (solid lines) and backward (dash lines) flow following pH 7.4 -> 6.2 -> 7.4 (a, N=35 multimers) or pH 7.4 -> 9.8 -> 7.4 (b, N=38 multimers) buffer exchanges. Black solid lines and the black dashed lines in (A) and (B) are the average and the standard deviation of the extension of individual molecules. They are also overlaid as blue, green and magenta lines in (C) and (D), to aid in comparing the results from indicated buffer exchanges. (E) Percentage of VWF compaction in pH 5.4 to 9.8 buffer.