3.

Factors associated with overall survival

Factors	Univariate			Multiple regression
	HR (95% CI)	P		HR (95% CI)	P
Age (years)	0.477 (0.275, 0.829)	0.009		0.492 (0.266, 0.909)	0.015
< 65	89
≥ 65	94
Gender	0.882 (0.504, 1.543)	0.66		–	–
Male	128
Female	55
Differentiation	0.576 (0.312, 1.135)	0.723		–	–
Well/moderately	152
Poorly	31
Comorbidities
Yes	108
No	75
Tumor size (cm)	1.916 (1.121, 3.274)	0.017		–	–
< 3	121
≥ 3	62
Tumor number	2.167 (1.205, 3.898)	0.01		1.969 (1.010, 3.839)	0.032
Single	147
Multiple	36
Adjacent to large vessels	2.571 (1.375, 4.808)	0.003		3.238 (1.508, 6.951)	0.002
Yes	153
No	30
α-fetoprotein level (ng/mL)	2.109 (1.231, 3.618)	0.007		1.898 (1.042, 3.456)	0.009
≤ 20	118
> 20	65
GGT (U/L)	1.872 (1.178, 2.287)	0.112		–	–
≤ 50	77
> 50	106
Albumin level (g/L)	0.703 (0.405, 1.220)	0.21		–	–
< 35	50
≥ 35	131
Total bilirubin level (μmol/L)	1.320 (0.706, 2.466)	0.384		–	–
< 20.5	150
≥ 20.5	33
ALT level (U/L)	1.257 (0.740, 2.135)	0.398		–	–
< 40	89
≥ 40	94
AST level (U/L)	1.345 (0.743, 2.434)	0.328		–	–
< 40	60
≥ 40	123
Platelet count (109)	0.772 (0.456, 1.306)	0.334		0.479 (0.258, 0.889)	0.027
<100	99
≥ 100	84
Prothrombin time international normalized ratio	1.012 (0.582, 1.760)	0.967		–	–
< 1.1	117
≥ 1.1	66
Procedure session	2.148 (1.002, 4.603)	0.049		–	–
1	162
> 1	21
Child–Pugh grade	2.119 (0.654, 6.868)	0.211		6.752 (1.728 26.384)	0.002
A	175
B	8
ALBI grade	3.787 (2.117, 6.775)	<0.001		4.814 (2.471, 9.378)	<0.001
1	95
2, 3	88
Data in parentheses are 95% confidence intervals. ALBI, albumin- bilirubin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyl transferase.